Loette® is an oral hormonal contraceptive containing low dosages of both estrogen and progestin. Despite the lower hormonal strengths present in Loette®, it offers contraceptive efficacy that is among the best in class. Loette® is also successfully used in women with a variety of hyper-androgenic disorders (e.g., acne, oily skin, excessive facial and truncal hair).

Description

Loette® is a new low-dose monophasic combined oral contraceptive manufactured by Wyeth Ltd (brand owned by Pfizer). It is composed of two active ingredients - Levonorgestrel and Ethinyl Estradiol.

Ethinyl Estradiol is a synthetic female hormone which belongs to the drug class called estrogens. It is responsible for the development and maintenance of menstrual cycle and is beneficial in the treatment of menstrual disorders. Levonorgestrel is a synthetic progesterone (progestin), another female sex hormone.

Contraception: Ethinyl Estradiol and Levonorgestrel inhibit the secretion of gonadotropins (follicle stimulating hormone, FSH and luteinizing hormone, LH). Ethinyl Estradiol stops ovaries from releasing an egg, while Levonorgestrel does not allow sperm fertilize any egg that may have already released, stops a fertilized egg from implanting itself to womb lining.

Hyperandrogenic problems: Continuous Loette® usage increases levels of Sex Hormone Binding Globulin (SHBG) - a protein substance in the blood stream that has a particular binding affinity to androgens. This leads to decreased quantity of androgens that freely circulate in the blood, therefore hyperandrogenic disorders like acne, hirsutism, oily skin, increased insulin resistance and blood sugar levels are significantly relieved.

Menstrual cycle control: taking Loette® on a regular basis results in reducing of menstrual disorders like dysmenorrhoea or pain during periods. Such cycle regulation is desirous in women who suffer from irregular or dysfunctional uterine bleeding out of various causes. Thus Loette® significantly relieves the PMS (premenstrual syndrome). PMS is a broad term used to label such a collection of menstrual problems (bloating, breast pain, groin aches, weak limbs, generalized fatigue, headache, mood swings and rarely visual disturbances) that present in the 3-4 day period around menses.

Cancer Prophylaxis: Taking Loette® for at least 3-4 years can prevent certain types of female genital tract cancer such as ovarian cancer and endometrial cancer (womb cancer). Even after stopping Loette®, these prophylactic benefits last for up to 10 years further.

Additional indications for taking Loette® are various benign gynecological conditions like fibroids in the uterus, pelvic inflammation, endometriosis, pelvic pain, ovarian cysts, fibrocystic breast disease and iron deficiency anemia. Loette® decreases the risk of blood clots due to the contents of second-generation progestin.

Loette® doesn't protect you and your partner from sexually transmitted diseases (HIV and the others).

Dosage

Take one tablet a day orally, with food or after the meal.

Do not crush or chew the tablet. Swallow the tablet whole with water.

The cycle of using Loette® takes 21 days.

Take one tablet daily for 21 days consecutively.

To achieve maximum contraceptive effectiveness, Loette® must be taken exactly as directed and at intervals not exceeding 24 hours.

It is recommended to take Loette® tablets at the same time each day.

Start the cycle of Loette® according to its package directions (on the first day of your menstrual period or on the first Sunday of your menstrual period).

After the last tablet, you should begin with the next package of Loette® on the next day.

While taking Loette® you may experience the breakthrough bleeding. Tell your doctor if this bleeding continues or is very heavy.

Missing a dose

If you miss a tablet, take the dose as soon as you remember about the missing or take two tablets at the time of your next regularly scheduled dose. You do not need to use another birth control. Note, that missing a dose increases your risk of becoming pregnant.

If you miss 2 tablets in a row during the first or second week, take two tablets each for the next two regularly scheduled doses (one missed tablet plus one regularly scheduled tablet for 2 days in a row). Use another form of birth control for at least 7 days following the missed tablets.

If you miss 2 tablets in a row during the third week, or if you miss 3 tablets in a row during any of the first 3 weeks, throw out the rest of the pack and start a new package on the same day if you are a Day 1 starter. If you are a Sunday starter, keep taking a pill every day until Sunday.

On Sunday, throw out the rest of the pack and start a new pack of pills that same day. You may not have a period that month, but this is expected. However, if you miss your period 2 months in a row, call your doctor because you might be pregnant.

If you miss a tablet, you may become pregnant if you have sex in the 7 days after you missed it. You must use another birth control method (e.g., condoms, spermicides) as a back-up for those 7 days.

Overdose

If an overdose occurs and you are feeling unwell, you should seek emergency medical attention or contact your healthcare provider immediately. Symptoms of overdose are unusual vaginal bleeding, feeling drowsy, vomiting, extreme tiredness, nausea.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) and away from excess moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Loette® are:

migraine
lightheadedness
vomiting
scalp hair loss
pain of the breast
nausea
vaginal itching
increasing of hair growth
stomach cramps
weight changes
problems with menstrual period
dark face
appetite changes
tiredness
problems with sexual life
nervousness
contact lenses problems

The most common side effects associated with Loette® are:

migraine
lightheadedness
vomiting
scalp hair loss
pain of the breast
nausea
vaginal itching
increasing of hair growth
stomach cramps
weight changes
problems with menstrual period
dark face
appetite changes
tiredness
problems with sexual life
nervousness
contact lenses problems

Less common side effects include:

allergic reactions (urticaria, breathing difficulties, rash, and eruption)
stomach pain
yellowing eyes or skin
breast lump
problems with vision
chest pain
problems with appetite
sudden numbness
clay-colored stools
sudden weakness
dark urine
depression
sudden migraine
sweating
confusion
problems with speech
pain which spreads to the shoulder or arm
problems with balance

Side effects occurrence does not only depend on the medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Loette® if you are allergic to its components.

Do not take Loette® if you are using another oral contraception.

Do not take Loette® if you are pregnant, plan to have a baby, or during lactation.

Do not take Loette® if you suffer from or have a history of jaundice; liver disease; stroke; breast, liver or uterine cancer; unusual vaginal bleeding; blood clot; heart valve disorder; problems with circulation; severe high blood pressure.

Do not smoke while taking Loette® because it can cause heart attack, stroke or blood clots.

Loette® can make your skin more sensitive to sunlight. So, try to protect your skin.

Do not take Loette® if you are taking antibiotics: amoxicillin (e.g., Augmentin), ampicillin (e.g., Omnipen), doxycycline (e.g., Vibramycin, Doryx), griseofulvin (e.g., Grifulvin V, Fulvicin PG, Grisactin), minocycline (e.g., Minocin), penicillin (e.g., Bicillin, Veetids, Pen-Vee K), rifampin (e.g., Rifadin), rifabutin (e.g., Mycobutin), tetracycline (e.g., Robitet, Sumycin, Achromycin).

Do not take Loette® if you are also taking barbiturates: barbiturate (e.g., Amytal), butabarbital (e.g., Butisol), mephobarbital (e.g., Mebaral), secobarbital (e.g., Seconal) or phenobarbital (e.g., Solfoton, Luminal).

Do not take Loette® if you are also taking ascorbic acid (e.g., Vitamin C) or acetaminophen (e.g., Tylenol).

Do not take Loette® if you are also taking HIV medicines: amprenavir (e.g., Agenerase), atazanavir (e.g., Reyataz), tipranavir (e.g., Aptivus), indinavir (e.g., Crixivan), saquinavir (e.g., Invirase), ritonavir (e.g., Kaletra), fosamprenavir (e.g., Lexiva), ritonavir (e.g., Norvir) or nelfinavir (e.g., Viracept).

Do not take Loette® if you are also taking phenylbutazone (e.g., Butazolidin, Azolid).

Do not take Loette® if you are also taking seizure medicines: phenytoin (e.g., Dilantin), carbamazepine (e.g., Tegretol), felbamate (e.g., Felbatol), oxcarbazepine (e.g., Trileptal), topiramate (e.g., Topamax), or primidone (e.g., Mysoline).

Do not take Loette® if you are also taking St. John's Wort.

Be careful with Loette® if you suffer from or have a history of asthma, chest pain, heart condition, gallbladder or fibrocystic breast diseases, irregular menstrual periods, high blood pressure, high cholesterol, lumps, nodules, congestive heart failure, diabetes, epilepsy, depression.

Be careful with Loette® if you are going to have a surgery (dental or other).

Do not consume alcohol while taking Loette®, as it may cause excessive drowsiness, calmness, minor side effects.

Loette® doesn't protect you and your partner from sexually transmitted diseases (HIV and the others). Keep Loette® away from children and don't give it to other people for using.

Q: What is Loette®?

A: Loette® is an oral hormonal contraceptive containing low dosages of both estrogen and progestin. Despite the lower hormonal strengths present in Loette®, it offers contraceptive efficacy that is among the best in class. Loette® is also successfully used in women with a variety of hyper-androgenic disorders (e.g., acne, oily skin, excessive facial and truncal hair).

Q: Can I smoke while taking Loette®?

A: Do not smoke cigarettes while taking Loette® because it can cause heart attack, stroke or blood clots.

Q: What should I do if I overdose?

A: If an overdose occurs and you are feeling unwell, you should seek emergency medical attention or contact your healthcare provider immediately. Symptoms of overdose are unusual vaginal bleeding, feeling drowsy, vomiting, extreme tiredness, nausea.

Q: How does Loette® work?

A: Ethinyl Estradiol stops ovaries from releasing an egg, while Levonorgestrel does not allow sperm fertilize any egg that may have already released, stops a fertilized egg from implanting itself to womb lining. Continuous Loette® usage increases levels of Sex Hormone Binding Globulin (SHBG) - a protein substance in the blood stream that has a particular binding affinity to androgens. This leads to decreased quantity of androgens that freely circulate in the blood, therefore hyperandrogenic problems like acne, hirsutism, oily skin are significantly relieved.

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